Point-of-care diagnostic aims to use fingerstick blood, serum, or plasma sample to detect typhoid fever
(BOSTON: February 5, 2026) – CARB-X is awarding US$1.8 million to Chembio Diagnostic Systems, Inc. to develop a rapid point-of-care test for the detection of Immunoglobulin A (IgA) antibodies to diagnose acute infection of Salmonella enterica serovar Typhi.
Typhoid fever is a severe systemic illness caused by the Gram-negative Salmonella enterica serovar Typhi. Each year, there are between 11 and 21 million cases of typhoid fever, with the greatest burden among children and individuals living in low- and middle-income countries (LMICs) in South Asia, and Southeast Asia and sub-Saharan Africa. The illness is responsible for approximately 128,000 to 161,000 deaths globally, and its symptoms include abdominal pain and fever. Typhoid fever is usually spread through the consumption of contaminated food or water.
Chembio will develop a direct from blood point-of-care test for IgA antibody detection based on its proprietary Dual Path Platform® technology for the detection of two biomarkers (LPS and HlyE) with high accuracy for detecting enteric fever. The IgA antibody detection is intended to better identify acute infection, rather than previous infection or vaccination, representing the potential for a notable improvement in diagnostic accuracy over existing rapid tests for typhoid fever.
The CARB-X award will also support Chembio’s work in differentiating between Salmonella species, characterizing test performance over a range of time points post-fever onset, and assessing performance on sample sets in Africa, where the disease burden is particularly high.
“A rapid, fingerstick-based test that delivers reliable results at the point of care could significantly improve how typhoid fever is diagnosed in low- and middle-income countries, where access to laboratory infrastructure is often limited,” said Richard Alm, Interim Chief of Research & Development at CARB-X. “If successful, Chembio’s diagnostic capability can support better clinical decision-making, strengthen surveillance and stewardship efforts, and contribute to more effective management of enteric fever in high-burden settings.”
“We are honored to receive funding from the CARB-X to develop our innovative rapid test to detect acute typhoid fever and ensure timely, appropriate treatment and minimize selective pressure for antimicrobial resistance,” said Javan Esfandiari, President of Chembio, a wholly owned subsidiary of Biosynex Group, a point-of-care diagnostics company with research, production and distribution subsidiaries in the United States, Europe, and Asia.
When CARB-X was founded in 2016, the early-stage antibacterial pipeline was stalled. Since its inception, CARB-X has supported 122 R&D projects in 14 countries, and CARB-X product developers have made significant progress: 24 projects have advanced into or completed clinical trials; 14 remain active in clinical development, including late-stage clinical trials; and 3 products have reached the market. Additionally, more than 10 product developers with active R&D projects have already secured advanced development partnerships to support their clinical development after leaving the CARB-X portfolio. All CARB-X-funded product developers are contractually obligated to develop a Stewardship and Access Plan for their product, outlining strategies to ensure responsible stewardship and appropriate access in low- and middle-income countries.
CARB-X is funded in part with federal funds from the U.S. Department of Health and Human Services (HHS); Administration for Strategic Preparedness and Response; Biomedical Advanced Research and Development Authority (BARDA) under agreement number 75A50122C00028 and by awards from Wellcome (WT224842), the UK Department of Health and Social Care’s Global Antimicrobial Resistance Innovation Fund (GAMRIF), the Gates Foundation, Germany’s Federal Ministry of Research, Technology and Space (BMFTR), the Public Health Agency of Canada (PHAC), the Novo Nordisk Foundation, Italy’s Ministry of Economy and Finance (MEF), and Japan’s Ministry of Health. The U.S. National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH) in HHS, provides support in the form of in-kind services through access to a suite of preclinical services for product development. The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of any CARB-X funders.
CARB-X Contact: Marissa Novel, carbxpr@bu.edu
Chembio Contact: Javan Esfandiari, jesfandiari@chembio.com
About CARB-X
CARB-X (Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator) is a global non-profit partnership dedicated to supporting early-stage antibacterial research and development to address the rising threat of drug-resistant bacteria. CARB-X supports innovative therapeutics, preventatives and rapid diagnostics. CARB-X is led by Boston University and funded by a consortium of governments and foundations. CARB-X funds only projects that target the most serious, resistant bacteria identified on global priority lists, syndromes with the greatest global morbidity and mortality, and performance characteristics necessary for patients. https://carb-x.org/ | X (formerly Twitter) @CARB_X
About Chembio Diagnostic Systems, Inc.
Chembio Diagnostic Systems, Inc., a subsidiary of the Biosynex Group, is a leading diagnostics company focused on the development, manufacture, and commercialization of point-of-care tests for infectious diseases. The company’s proprietary DPP® technology platform delivers high-quality, accurate results within minutes, supporting rapid diagnosis and improved patient outcomes worldwide. For more information, visit www.chembio.com.
About BIOSYNEX
Founded in 2005, the French laboratory BIOSYNEX is a leading health diagnostics group, specializing in rapid tests, biotherapy monitoring, and molecular biology.
As a forward-thinking player in the future of medicine, BIOSYNEX advocates for the improvement of healthcare pathways and offers innovative health solutions to a variety of users, including laboratories, hospitals, doctors, and the general public, aimed at enhancing overall patient care.
The Group now has research, production, and distribution subsidiaries in the United States, Europe, and Asia, supporting its two business units: BIOSYNEX PHARMACY and BIOSYNEX DIAGNOSTICS. For more information, visit www.biosynex.com.
About BARDA and NIAID
The U.S. Department of Health and Human Services works to enhance and protect the health and well-being of all Americans, providing for effective health and human services and fostering advances in medicine, public health, and social services. The Administration for Strategic Preparedness and Response leads the nation’s medical and public health preparedness for, response to and recovery from disaster and other public health emergencies. Within ASPR, the Biomedical Advanced Research and Development Authority (BARDA) invests in innovation, advanced research and development, acquisition, and manufacturing of medical countermeasures needed to combat health security threats. BARDA is one of the leading public sector funders of advanced development of antimicrobial therapeutics and diagnostics worldwide, having invested more than $2.7 billion in antimicrobial products since 2010. This investment has supported the development of over 190 antimicrobial products and led to the U.S. Food and Drug Administration (FDA) approval of six new antibiotics and FDA 510(k) clearance of 10 diagnostics.
As part of HHS, NIH is the primary U.S. federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. NIAID conducts and supports research — at NIH, throughout the United States, and worldwide — to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses.
About Wellcome
Wellcome supports science to solve the urgent health challenges facing everyone. We support discovery research into life, health and wellbeing, and we’re taking on three worldwide health challenges: mental health, infectious disease and climate and health.
About the German Federal Ministry of Research, Technology, and Space and Research (BMFTR)
Research and innovation are the foundations for our future. The promotion of science and research by BMFTR represents an important contribution to securing Germany’s prosperity. Research is a German Federal Government policy priority, which is reflected in the development of the funding it is making available to these fields.
About the Global AMR Innovation Fund (GAMRIF)
The Global AMR Innovation Fund (GAMRIF) is a One Health aid fund that supports research and development around the world to reduce the threat of antimicrobial resistance (AMR) in humans, animals and the environment for the benefit of people in low- and middle-income countries (LMICs). GAMRIF core objectives are to develop innovative One Health solutions to tackle AMR; increase availability of context-specific, accessible, and affordable innovations for LMICs; establish international research partnerships with industry, academia, and governments; and collaborate with and leverage additional funding from other global donors.
About the Public Health Agency of Canada
The Public Health Agency of Canada (PHAC), established in 2004, is responsible for public health, emergency preparedness and response, and infectious and chronic disease control and prevention. Its mission is to improve the health of all people and communities in Canada by addressing public health priorities through science, innovation, service delivery, and collaborative action. The Agency collaborates closely with all levels of government, non-government organizations, and international partners to build an effective public health system. PHAC has a strong history of addressing health threats, including collaboration on a One Health approach to antimicrobial resistance (AMR). As part of the Pan-Canadian Action Plan on AMR 2023-2027, PHAC is developing an economic pull-incentive pilot project which aims to increase access to essential antimicrobial drugs not yet market-authorized in Canada to address priority unmet public health needs.
About the Novo Nordisk Foundation
Established in Denmark in 1924, the Novo Nordisk Foundation is an enterprise foundation with philanthropic objectives. The vision of the Foundation is to improve people’s health and the sustainability of society and the planet. The Foundation’s mission is to progress research and innovation in the prevention and treatment of cardiometabolic and infectious diseases as well as to advance knowledge and solutions to support a green transformation of society. www.novonordiskfonden.dk/en
Ministry of Economy and Finance of Italy
The Italian Ministry of Economy and Finance (MEF) performs the functions and tasks incumbent on the State in matters of economic and financial policy, budgeting, public investment planning and public debt management. The Ministry’s activities include coordinating and monitoring public spending and its trends, tax policies and the tax system and state assets. Moreover, the Ministry represents the Italian Government in the main European and international economic and financial fora, performs functions related to global governance and international financial cooperation, maintains relations with international economic, monetary, and financial institutions (such as the IMF, OECD, and Multilateral Development Banks), and negotiates and concludes international agreements and treaties with economic and financial content.
Japan’s Ministry of Health, Labour and Welfare (MHLW)
MHLW is a ministry of the Government of Japan whose missions are to improve and promote social welfare, social security, and public health in order to secure and improve the livelihoods of the people and contribute to economic development. Recognizing the urgent global public health threat posed by AMR, MHLW has been supporting various domestic and international efforts to advance research and development of antimicrobials. MHLW has committed to providing contributions to CARB-X from 2024 to 2026.
About Boston University
Founded in 1839, Boston University is an internationally recognized institution of higher education and research. With nearly 37,000 students, it is one of the largest private residential universities in the United States. BU consists of 17 schools and colleges, along with the Faculty of Computing & Data Sciences and a number of multi-disciplinary centers and institutes integral to the University’s research and teaching mission. In 2012, BU joined the Association of American Universities (AAU), a consortium of leading research universities in the United States and Canada. For further information, please contact Kim Miragliuolo at kmira@bu.edu. www.bu.edu