News

Antibiotic Resistance

  • 05.05.2022  |  Diagnostic stewardship tied to fewer blood cultures, antibiotics in sick kids

    CIDRAP | The JAMA Pediatrics study found that a national quality improvement collaborative to reduce the ordering of blood cultures to evaluate for bloodstream infections in children in pediatric intensive care units (PICUs) was associated both with fewer blood cultures and less broad-spectrum antibiotic use, without increasing the risk of bacterial sepsis or affecting mortality, hospital readmission, or the amount of time spent in the hospital.

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  • 05.04.2022  |  Candida auris Rapidly Recontaminates Surfaces Around Patients’ Beds Despite Cleaning and Disinfection

    INFECTION CONTROL TODAY | Candida auris (C auris) recontaminates environmental surfaces within a patient’s room within hours despite regular cleaning and disinfection. C auris is an emerging multidrug-resistant yeast that is often associated with substantial morbidity and mortality and is often transmitted in health care facilities. Investigators suspect environmental contamination plays an important role in transmission, but additional information is needed to inform environmental cleaning recommendations to prevent spread.

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  • 04.30.2022  |  Deadly MRSA superbug develops ‘bulletproof vest’ against highly potent antibiotic

    THE TELEGRAPH | The deadly superbug MRSA has evolved a “bulletproof vest” to protect itself against a “last resort” antibiotic used to treat the infection. Daptomycin is a highly potent antibiotic reserved for only the most serious cases. Yet despite restricted use, the bacteria is still managing to create new defences to protect itself.

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  • 04.26.2022  |  Antibiotic resistance is making neonatal sepsis harder to treat

    CIDRAP | A large observational study of newborn babies with sepsis shows the impact that antimicrobial resistance (AMR) is having on this vulnerable population. The study, led by the Global Antibiotic Research & Development Partnership (GARDP), looked at mortality, antibiotic treatments, and resistance among more than 3,200 newborns with suspected neonatal sepsis at hospitals in 11 countries and found that more than 11% died during the study period. The mortality rate ranged from 1% to as high as 27%.

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  • 04.26.2022  |  Entasis Therapeutics Presents Efficacy and Safety Data from Landmark Phase 3 ATTACK Trial at ECCMID 2022 Conference

    GLOBENEWSWIRE | Entasis Therapeutics, a late-stage clinical biopharmaceutical company focused on the discovery and development of novel antibacterial products, today announced that top-line data from the company’s pivotal Phase 3 ATTACK trial was presented at the 32nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) annual conference.

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  • 04.26.2022  |  Lori Burrows on the slow-moving pandemic of antimicrobial resistance

    BRIGHTER WORLD | COVID-19 continues to occupy the minds of infectious disease doctors but there’s another public health issue brewing – the growing number of drug-resistant bacteria and the lack of new antibiotics to treat them.

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  • 04.24.2022  |  Pigs can pass deadly superbugs to people, study reveals

    THE GUARDIAN | Scientists have uncovered evidence that dangerous versions of superbugs can spread from pigs to humans. The discovery underlines fears that intensive use of antibiotics on farms is leading to the spread of microbes resistant to them.

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  • 04.20.2022  |  Scientists record the sound of a single bacterium’s motion

    SALON | Thanks to a relatively new material, known as graphene, scientists were able to amplify frequencies of such nanomotion, which individual bacteria emit, and reproduce audio recordings. Via an ultra-thin bilayer membrane of graphene — the latest “spyware,” so-to-speak, in a decades-long arms race against antibacterial-resistant “superbugs” — they were able to rapidly distinguish living and deceased bacteria in a laboratory culture.

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  • 04.20.2022  |  Machine learning identifies antibiotic resistant bacteria that can spread between animals, humans and environment

    PHYS.ORG | Experts from the University of Nottingham have developed new software which combines DNA sequencing and machine learning to help them find where, and to what extent, antibiotic resistant bacteria is being transmitted between humans, animals and the environment.

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  • 04.19.2022  |  Scientists Work to Uncover Mechanisms Behind Bacterial Resistance

    PEW | To respond to this worsening problem of antimicrobial resistance, scholars and fellows within Pew’s biomedical research programs, along with other scientists, are searching for clues about how and why resistance occurs in bacteria that cause a range of conditions such as tuberculosis, pneumonia, and sepsis.

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  • 04.12.2022  |  Drug pollution in rivers raises risks of antibiotic resistance

    FINANCIAL TIMES | Lower middle income countries in South Asia and Latin America have some of the world’s highest levels of pharmaceutical pollutants in their rivers, raising concerns over the risk of bacteria developing resistance to antibiotics.

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  • 04.10.2022  |  Drug-resistant bacteria strains are turning simple infections into killers

    THE NEW DAILY | Patients who contract drug-resistant urinary tract infections can be more than three times more likely to die, according to a study by the CSIRO, Queensland University of Technology and Queensland University.

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  • 04.05.2022  |  CSIRO study finds antimicrobial resistance is making UTIs more deadly

    CSIRO | A new study led by Australia’s national science agency, CSIRO, has found the spread of drug-resistant bacteria in the community is increasing the risk of death for common infections such as urinary tract infections (UTIs), which affect around one in two women and one in 20 men in their lifetime.

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  • 03.19.2022  |  Shortage of new antibiotics stokes fears of a ‘silent pandemic’

    THE TIMES | In the 30 years that Dr Neil Todd has worked as a clinical microbiologist, he has watched as the number of antibiotics available to treat patients has grown fewer. In some cases — such as when patients arrive at hospital with sepsis — he is down to his last resort. “We’re now scraping the bottom of the barrel of the drugs we’ve got that we can use that way,” he said. “Once you get to about a 10 per cent resistance rate of an antibiotic, it becomes a bit of a gamble to give it to somebody with sepsis.”

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  • 02.28.2022  |  When Antibiotics Stop Working

    FOREIGN AFFAIRS | The world is fixated on viruses thanks to COVID-19. Public and private sectors have mobilized extraordinary levels of resources in tackling the pandemic, including developing vaccines in record time and antiviral and antiretroviral treatments for the disease. In the process, however, another major microbial threat has been neglected. In a study published in The Lancet in January, researchers at the University of Washington estimated that 1.3 million people die each year from bacterial infections that are resistant to antibiotics. Such infections kill more people annually than do HIV/AIDS, diarrhea, and malaria. Antibiotic resistance causes more deaths than any infectious disease apart from COVID-19 and tuberculosis.

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  • 02.24.2022  |  The Challenge of Convergent Crises

    PROJECT SYNDICATE | After more than two years of the COVID-19 pandemic, the global community has little interest in addressing the problem of drug-resistant pathogens. But highlighting the links between antimicrobial resistance, climate change, and violent conflict could encourage world leaders to reconsider their priorities.

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  • 02.19.2022  |  First antibiotic for super-gonorrhea enters human trials as new cases found in England

    THE TELEGRAPH | The first antibiotic for super-gonorrhoea has entered human trials. An estimated 82.4 million people were newly infected with gonorrhoea in 2020, with all these cases resistant to at least one antibiotic

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  • 02.17.2022  |  How vaccine science could help tackle antimicrobial resistance

    PHARMACEUTICAL TECHNOLOGY | In their ability to provide substantial protection against the worst effects of the novel coronavirus, vaccines are our ticket out of the Covid-19 pandemic – but research suggests they could also help us tackle another urgent threat to public health: antimicrobial resistance.

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  • 02.17.2022  |  The crisis of antimicrobial resistance in India

    DECCAN HERALD NEWS | Most antibiotics are half a century old and the overuse of these drugs has created an acute antimicrobial resistance (AMR) crisis worldwide which is claiming a large number of lives, including in India.

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  • 02.16.2022  |  GRAM paper findings

    WELLCOME | A video webinar on the GRAM paper findings that were published in The Lancet. The purpose of the Global Research on AntiMicrobial resistance (GRAM) Project is to generate accurate and timely estimates of the magnitude and trends in antimicrobial resistance (AMR) burden across the world, which can be used to inform treatment guidelines and agendas for decision-making and research, detect emerging problems and monitor trends to inform global strategies, as well as facilitate the assessment of interventions over time.

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  • 02.15.2022  |  Pharmaceuticals in rivers threaten world health – study

    BBC | Pollution of the world's rivers from medicines and pharmaceutical products poses a "threat to environmental and global health", a report says. The research is among the most extensive undertaken on a global scale.

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  • 01.28.2022  |  The shadow pandemic: Antibiotic resistance is growing

    THE WASHINGTON POST | Another global health crisis is unfolding in the shadow of the coronavirus pandemic. Antimicrobial resistance, the tendency of bacteria and other pathogens to evolve so they fight or evade lifesaving drugs, is a long-term threat to modern medicine.

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  • 01.20.2022  |  Millions are dying from drug-resistant infections, global report says

    BBC | More than 1.2 million people died worldwide in 2019 from infections caused by bacteria resistant to antibiotics, according to the largest study of the issue to date.

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  • 01.20.2022  |  Antimicrobial resistance now a leading cause of death worldwide, study finds

    THE GUARDIAN | Antimicrobial resistance poses a significant threat to humanity, health leaders have warned, as a study reveals it has become a leading cause of death worldwide and is killing about 3,500 people every day.

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  • 01.20.2022  |  Antibiotic resistance kills over 1m people a year, says study

    FINANCIAL TIMES | More than 1m people around the world die each year from infections linked to microbes resistant to antibiotics, according to a study that estimates the scale of a “silent pandemic” that is now more deadly than malaria or HIV.

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