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Antibiotic Resistance

  • 07.22.2022  |  Superbugs could cost you an arm or a leg: Why hospitals need more money to fight drug resistance

    BHEKISISA | Common germs are outsmarting medicine much faster than South Africa’s health system can keep up with — and new research suggests there isn’t the money (or enough specialists) at state facilities to stop more bugs from becoming untreatable.

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  • 07.19.2022  |  Drug-resilient bacteria threat rises with spread of world’s war zones

    Financial Times | Infected wounds are growing cause for concern in the Middle East, Ukraine and beyond.

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  • 07.19.2022  |  Antibiotic resistance raises prospect of untreatable gonorrhoea

    Financial Times | Just one drug remains effective for the sexually transmitted disease but soon the bacteria may be able to evade it.

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  • 07.15.2022  |  No antibiotics worked, so this woman turned to a natural enemy of bacteria to save her husband’s life

    CNN | In February 2016, infectious disease epidemiologist Steffanie Strathdee was holding her dying husband’s hand, watching him lose an exhausting fight against a deadly superbug infection.

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  • 07.14.2022  |  The Pandemic Fueled a Superbug Surge. Can Medicine Recover?

    WIRED | As Covid swept ICUs, doctors prescribed antibiotics to ward off secondary infections. Now bacteria have evolved resistance—but hospitals are fighting back.

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  • 07.13.2022  |  Drug-Resistant Infections in Hospitals Soared During the Pandemic

    NYT | A new report says the havoc wrought by the coronavirus reversed gains made by health care facilities to combat deadly pathogens.

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  • 07.13.2022  |  Superbug infections spiked in pandemic’s first wave

    NBC News | The spread of drug-resistant bacteria and fungi in 2020 erased the progress the U.S. made against these deadly germs.

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  • 07.13.2022  |  WHO report highlights progress, challenges for vaccines against resistant bacteria

    CIDRAP | The World Health Organization (WHO) today released its first-ever report on the pipeline for vaccines to combat antimicrobial resistance (AMR).

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  • 07.12.2022  |  National stewardship program tied to reduced antibiotics in ambulatory care

    CIDRAP | Antibiotic prescribing at hundreds of ambulatory care clinics across the country was nearly cut in half after implementation of an antibiotic stewardship and patient safety program.

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  • 07.12.2022  |  Pandemic fueled surge in superbug infections and deaths, CDC says

    Washington Post | Sicker patients, antibiotic overuse, and staff and equipment shortages led to 15 percent increase.

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  • 07.12.2022  |  U.S. deaths from antibiotic resistant ‘superbugs’ rose 15% in 2020

    Reuters | U.S. deaths from bacteria resistant to antibiotics, also known as ‘superbugs’, jumped 15% in 2020 as the drugs were widely dispensed to treat COVID-19 and fight off bacterial infections during long hospitalizations, enabling the bugs to evolve, a U.S. government report said on Tuesday.

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  • 07.12.2022  |  Urgent call for better use of existing vaccines and development of new vaccines to tackle AMR

    WHO | WHO today released the first-ever report on the pipeline of the vaccines currently in development to prevent infections caused by antimicrobial-resistant (AMR) bacterial pathogens. WHO’s analysis points to the need to accelerate trials for AMR related vaccines in late-stage development and maximise the use of existing vaccines.

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  • 07.12.2022  |  ‘Eye-opening’: The Covid-19 pandemic accelerated antimicrobial resistance across the U.S.

    STAT | Resistance to medicines for combating superbugs has considerably worsened during the pandemic, with deaths and infections from several serious pathogens increasing at least 15% during the first year of the crisis, according to a new report by the Centers for Disease Control and Prevention.

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  • 07.12.2022  |  Bacterial vaccines in clinical and preclinical development 2021

    WHO | “An analysis of bacterial vaccines in preclinical and clinical development: 2021” is the first WHO analyses and report of vaccine candidates in preclinical and clinical development in 2021, in the context of antimicrobial resistance (AMR).

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  • 07.11.2022  |  Healthcare asset manager Innoviva buys another biotech at a bargain price

    BioPharmaDive | Hospitals and doctors are in need of new medicines to combat drug-resistant bacteria strains. Development of new anti-infective drugs has been slow to materialize, however.

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  • 07.07.2022  |  Untreatable gonorrhoea on the rise worldwide

    Nature | Non-profit group helps marshal trial of a new antibiotic in an attempt to beat back resistant infections

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  • 07.06.2022  |  Cambridge microbiome company looks beyond fecal transplants

    Boston Globe | Vedanta Biosciences will use its new manufacturing facility to make bacteria-filled pills that heal the gut microbiome without the need for stool donors.

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  • 07.06.2022  |  $250B plan to end TB seeks new vaccine by 2025

    Devex | On Wednesday, the Stop TB Partnership launched an ambitious new plan to end tuberculosis by 2030, which includes the approval of a new TB vaccine by 2025.

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  • 07.04.2022  |  Buyers United: How Low- and Middle-Income Countries Can Get a Better Deal on Pharmaceuticals

    Inside View | The wider use of pooled procurement in national health systems can help low- and middle-income countries get a better deal on pharmaceuticals.

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  • 06.30.2022  |  UK leading race to develop new treatments to tackle drug-resistant infections, says Sajid Javid

    iNews | Health Secretary set to announce extra funding towards a global antibiotic research fund which is set to help millions of people in low-and middle-income countries

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  • 06.30.2022  |  More Promising Phage News—Using Bacteria-Killing Viruses To Treat Antibiotic-Resistant Infections

    Forbes | There’s more good news from the world of phages, viruses that infect bacteria, in treating antibiotic-resistant bacteria.

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  • 06.29.2022  |  ‘Global response’ needed as typhoid evades antibiotics

    SciDevNet | The bacteria that causes typhoid fever is becoming increasingly resistant to common antibiotics used to treat the disease, with these resistant strains spreading to hundreds of countries in the past three decades, new analysis shows.

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  • 06.29.2022  |  Vedanta opens manufacturing facility to produce lead candidate as it heads for PhIII

    Endpoints | The microbiome startup Vedanta, while still forging ahead with the Phase III process for its Clostridioides difficile infection candidate, has completed a manufacturing facility to produce the drug.

     

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  • 06.28.2022  |  What it would take to set up an African drug discovery ecosystem

    The Conversation | A factor holding back African research is the lack of strong collaborative networks between African laboratories and institutions.

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  • 06.28.2022  |  COVID-19 & Antibiotic Resistance

    CDC | The U.S. lost progress combating antimicrobial resistance in 2020 due, in large part, to effects of the COVID-19 pandemic. The CDC concluded that the threat of antimicrobial-resistant infections is not only still present but has gotten worse.

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  • 06.17.2022  |  New Strain of Extensively Drug-Resistant Gonorrhea Appears in Austria

    Gizmodo | The rise of super gonorrhea continues unabated. Scientists in Europe say they’ve recently discovered a new strain of extensively drug-resistant gonorrhea—the second such strain to be found worldwide in recent years.

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  • 06.13.2022  |  Study aims to improve tests to predict antibiotic resistance

    Independent | Researchers are hoping to better predict resistance to new antibiotics before it occurs in patients.

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  • 06.09.2022  |  Drugmakers urged to give poorer nations access to more antibiotics

    The Guardian | Antifungals also needed, says study, as drug resistance has increased faster than expected, particularly in sub-Saharan Africa

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  • 06.02.2022  |  3 reasons for unprecedented world hunger

    Politico | “AMR is a pandemic, and in many ways, it’s also similar to the challenges which we’re trying to face in the pandemic treaty,” Lena Hallengren, Sweden’s minister of health and social affairs told Global Pulse during an interview at the Swedish embassy in Washington, D.C.

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  • 06.01.2022  |  Inappropriate antibiotic prescribing in kids cost $74M in excess in 2017, Pew study finds

    Fierce | Inappropriate prescribing of antibiotics in non-hospitalized children led to at least $74 million in excess healthcare costs in 2017, a new study found.

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  • 05.27.2022  |  Scientists develop a phone app to help fight antimicrobial resistance

    The Telegraph | The app could play an important part in tackling the looming threat posed by superbugs

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  • 05.25.2022  |  Vaccines hold potential to curb antibiotic resistance

    FINANCIAL TIMES | The battle against antibiotic resistance is often portrayed as a race between pharmaceutical science and bacterial evolution. Yet health experts warn that prevention is better than cure — and the potential of vaccines in combating drug-resistant infections is often overlooked.

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  • 05.25.2022  |  Diagnostic tests a crucial tool in fight against antibiotic resistance

    FINANCIAL TIMES | Identifying conditions can prevent inappropriate drug use, but there are barriers to progress in poorer regions

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  • 05.23.2022  |  Anand Anandkumar at Bugworks on how India could become a powerhouse of biotech research

    FORBES INDIA DAILY TECH CONVERSATION PODCAST | Anand Anandkumar, CEO of Bugworks Research, talks about the many challenges of commercializing scientific breakthroughs from India. He also talks about the opportunity for this country to become a biotech powerhouse. Bugworks is a clinical phase drug discovery company that is attempting to develop a new class of antibiotics to tackle antimicrobial resistance.

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  • 05.19.2022  |  The Importance of Antimicrobial Stewardship in Patients Coinfected with COVID-19 and Sepsis

    CONTAGION LIVE | Patients hospitalized with severe COVID-19 are more likely to develop secondary infections, often initiated on antibiotics, that could lead to sepsis. These patients who present with sepsis, “a clinical condition of life-threatening organ dysfunction which is caused by an abnormal response to infection,” are at even greater risk of death.

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  • 05.13.2022  |  ‘Phage therapy’ successes boost fight against drug-resistant infections

    Guardian | Two US patients recover from intractable infections, giving hope for treatments beyond antibiotics

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  • 05.12.2022  |  Multi-pathogen testing is the future of diagnostics

    The Telegraph | As we rebuild and strengthen health systems ravaged by the pandemic, let’s change the question from ‘is it Covid?’ to ‘what is this?

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  • 05.10.2022  |  Antibiotic resistance is threatening our health. Will bacterial infection send us back to the medical dark age?

    ABC Australia | Over the past 12 years, two scientists have been developing a new antibiotic that recently began phase 1 clinical trials in the US. This promising new drug, with the uninspiring name QPX9003, has placed the pair on the cusp of achieving something that hasn’t been done for decades.

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  • 05.05.2022  |  What Happens to the Gut Microbiome After Taking Antibiotics?

    The Scientist | Studies are finding that a single course of antibiotics alters the gut microbiomes of healthy volunteers—and that it can take months or even years to recover the original species composition.

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  • 05.05.2022  |  Diagnostic stewardship tied to fewer blood cultures, antibiotics in sick kids

    CIDRAP | The JAMA Pediatrics study found that a national quality improvement collaborative to reduce the ordering of blood cultures to evaluate for bloodstream infections in children in pediatric intensive care units (PICUs) was associated both with fewer blood cultures and less broad-spectrum antibiotic use, without increasing the risk of bacterial sepsis or affecting mortality, hospital readmission, or the amount of time spent in the hospital.

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  • 05.04.2022  |  Candida auris Rapidly Recontaminates Surfaces Around Patients’ Beds Despite Cleaning and Disinfection

    INFECTION CONTROL TODAY | Candida auris (C auris) recontaminates environmental surfaces within a patient’s room within hours despite regular cleaning and disinfection. C auris is an emerging multidrug-resistant yeast that is often associated with substantial morbidity and mortality and is often transmitted in health care facilities. Investigators suspect environmental contamination plays an important role in transmission, but additional information is needed to inform environmental cleaning recommendations to prevent spread.

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  • 05.02.2022  |  COVID-19 may have led to a spike in antibiotic resistance

    Medical News Today | Antibiotic resistance has been on the rise in the United States during the COVID-19 pandemic.

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  • 04.30.2022  |  Deadly MRSA superbug develops ‘bulletproof vest’ against highly potent antibiotic

    THE TELEGRAPH | The deadly superbug MRSA has evolved a “bulletproof vest” to protect itself against a “last resort” antibiotic used to treat the infection. Daptomycin is a highly potent antibiotic reserved for only the most serious cases. Yet despite restricted use, the bacteria is still managing to create new defences to protect itself.

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  • 04.26.2022  |  Antibiotic resistance is making neonatal sepsis harder to treat

    CIDRAP | A large observational study of newborn babies with sepsis shows the impact that antimicrobial resistance (AMR) is having on this vulnerable population. The study, led by the Global Antibiotic Research & Development Partnership (GARDP), looked at mortality, antibiotic treatments, and resistance among more than 3,200 newborns with suspected neonatal sepsis at hospitals in 11 countries and found that more than 11% died during the study period. The mortality rate ranged from 1% to as high as 27%.

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  • 04.26.2022  |  Entasis Therapeutics Presents Efficacy and Safety Data from Landmark Phase 3 ATTACK Trial at ECCMID 2022 Conference

    GLOBENEWSWIRE | Entasis Therapeutics, a late-stage clinical biopharmaceutical company focused on the discovery and development of novel antibacterial products, today announced that top-line data from the company’s pivotal Phase 3 ATTACK trial was presented at the 32nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) annual conference.

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  • 04.26.2022  |  Lori Burrows on the slow-moving pandemic of antimicrobial resistance

    BRIGHTER WORLD | COVID-19 continues to occupy the minds of infectious disease doctors but there’s another public health issue brewing – the growing number of drug-resistant bacteria and the lack of new antibiotics to treat them.

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  • 04.24.2022  |  Pigs can pass deadly superbugs to people, study reveals

    THE GUARDIAN | Scientists have uncovered evidence that dangerous versions of superbugs can spread from pigs to humans. The discovery underlines fears that intensive use of antibiotics on farms is leading to the spread of microbes resistant to them.

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  • 04.20.2022  |  Scientists record the sound of a single bacterium’s motion

    SALON | Thanks to a relatively new material, known as graphene, scientists were able to amplify frequencies of such nanomotion, which individual bacteria emit, and reproduce audio recordings. Via an ultra-thin bilayer membrane of graphene — the latest “spyware,” so-to-speak, in a decades-long arms race against antibacterial-resistant “superbugs” — they were able to rapidly distinguish living and deceased bacteria in a laboratory culture.

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  • 04.20.2022  |  Machine learning identifies antibiotic resistant bacteria that can spread between animals, humans and environment

    PHYS.ORG | Experts from the University of Nottingham have developed new software which combines DNA sequencing and machine learning to help them find where, and to what extent, antibiotic resistant bacteria is being transmitted between humans, animals and the environment.

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  • 04.19.2022  |  Scientists Work to Uncover Mechanisms Behind Bacterial Resistance

    PEW | To respond to this worsening problem of antimicrobial resistance, scholars and fellows within Pew’s biomedical research programs, along with other scientists, are searching for clues about how and why resistance occurs in bacteria that cause a range of conditions such as tuberculosis, pneumonia, and sepsis.

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  • 04.12.2022  |  Drug pollution in rivers raises risks of antibiotic resistance

    FINANCIAL TIMES | Lower middle income countries in South Asia and Latin America have some of the world’s highest levels of pharmaceutical pollutants in their rivers, raising concerns over the risk of bacteria developing resistance to antibiotics.

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  • 04.10.2022  |  Drug-resistant bacteria strains are turning simple infections into killers

    THE NEW DAILY | Patients who contract drug-resistant urinary tract infections can be more than three times more likely to die, according to a study by the CSIRO, Queensland University of Technology and Queensland University.

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  • 04.06.2022  |  How drug-resistant pathogens in water could spark another pandemic

    UN ENVIRONMENT PROGRAMME | People around the world are unknowingly being exposed to water laced with antibiotics, which could spark the rise of drug-resistant pathogens and potentially fuel another global pandemic, warns a report from the United Nations Environment Programme (UNEP).

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  • 04.05.2022  |  CSIRO study finds antimicrobial resistance is making UTIs more deadly

    CSIRO | A new study led by Australia’s national science agency, CSIRO, has found the spread of drug-resistant bacteria in the community is increasing the risk of death for common infections such as urinary tract infections (UTIs), which affect around one in two women and one in 20 men in their lifetime.

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  • 03.19.2022  |  Shortage of new antibiotics stokes fears of a ‘silent pandemic’

    THE TIMES | In the 30 years that Dr Neil Todd has worked as a clinical microbiologist, he has watched as the number of antibiotics available to treat patients has grown fewer. In some cases — such as when patients arrive at hospital with sepsis — he is down to his last resort. “We’re now scraping the bottom of the barrel of the drugs we’ve got that we can use that way,” he said. “Once you get to about a 10 per cent resistance rate of an antibiotic, it becomes a bit of a gamble to give it to somebody with sepsis.”

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  • 02.28.2022  |  When Antibiotics Stop Working

    FOREIGN AFFAIRS | The world is fixated on viruses thanks to COVID-19. Public and private sectors have mobilized extraordinary levels of resources in tackling the pandemic, including developing vaccines in record time and antiviral and antiretroviral treatments for the disease. In the process, however, another major microbial threat has been neglected. In a study published in The Lancet in January, researchers at the University of Washington estimated that 1.3 million people die each year from bacterial infections that are resistant to antibiotics. Such infections kill more people annually than do HIV/AIDS, diarrhea, and malaria. Antibiotic resistance causes more deaths than any infectious disease apart from COVID-19 and tuberculosis.

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  • 02.24.2022  |  The Challenge of Convergent Crises

    PROJECT SYNDICATE | After more than two years of the COVID-19 pandemic, the global community has little interest in addressing the problem of drug-resistant pathogens. But highlighting the links between antimicrobial resistance, climate change, and violent conflict could encourage world leaders to reconsider their priorities.

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  • 02.19.2022  |  First antibiotic for super-gonorrhea enters human trials as new cases found in England

    THE TELEGRAPH | The first antibiotic for super-gonorrhoea has entered human trials. An estimated 82.4 million people were newly infected with gonorrhoea in 2020, with all these cases resistant to at least one antibiotic

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  • 02.17.2022  |  How vaccine science could help tackle antimicrobial resistance

    PHARMACEUTICAL TECHNOLOGY | In their ability to provide substantial protection against the worst effects of the novel coronavirus, vaccines are our ticket out of the Covid-19 pandemic – but research suggests they could also help us tackle another urgent threat to public health: antimicrobial resistance.

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  • 02.17.2022  |  The crisis of antimicrobial resistance in India

    DECCAN HERALD NEWS | Most antibiotics are half a century old and the overuse of these drugs has created an acute antimicrobial resistance (AMR) crisis worldwide which is claiming a large number of lives, including in India.

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  • 02.16.2022  |  GRAM paper findings

    WELLCOME | A video webinar on the GRAM paper findings that were published in The Lancet. The purpose of the Global Research on AntiMicrobial resistance (GRAM) Project is to generate accurate and timely estimates of the magnitude and trends in antimicrobial resistance (AMR) burden across the world, which can be used to inform treatment guidelines and agendas for decision-making and research, detect emerging problems and monitor trends to inform global strategies, as well as facilitate the assessment of interventions over time.

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  • 02.15.2022  |  Pharmaceuticals in rivers threaten world health – study

    BBC | Pollution of the world's rivers from medicines and pharmaceutical products poses a "threat to environmental and global health", a report says. The research is among the most extensive undertaken on a global scale.

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  • 01.28.2022  |  The shadow pandemic: Antibiotic resistance is growing

    THE WASHINGTON POST | Another global health crisis is unfolding in the shadow of the coronavirus pandemic. Antimicrobial resistance, the tendency of bacteria and other pathogens to evolve so they fight or evade lifesaving drugs, is a long-term threat to modern medicine.

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  • 01.20.2022  |  Millions are dying from drug-resistant infections, global report says

    BBC | More than 1.2 million people died worldwide in 2019 from infections caused by bacteria resistant to antibiotics, according to the largest study of the issue to date.

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  • 01.20.2022  |  Antimicrobial resistance now a leading cause of death worldwide, study finds

    THE GUARDIAN | Antimicrobial resistance poses a significant threat to humanity, health leaders have warned, as a study reveals it has become a leading cause of death worldwide and is killing about 3,500 people every day.

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  • 01.20.2022  |  Antibiotic resistance kills over 1m people a year, says study

    FINANCIAL TIMES | More than 1m people around the world die each year from infections linked to microbes resistant to antibiotics, according to a study that estimates the scale of a “silent pandemic” that is now more deadly than malaria or HIV.

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