Vaccines Against Clostridium difficile Infection (CDI): A Roadmap for the Future

NIAID Conference Center 5601 Fishers Lane, Rockville, MD, United States

There are 453K new C. difficile infections (CDI) every year and 83K recurrent infections, yet there are no licensed vaccines against this important nosocomial pathogen. The current pipeline of clinical-stage vaccines consists of two toxin-based candidates and one phase 3 candidate, which is no longer being pursued. Although mathematical studies and computer-simulation models suggest that […]