WHO BULLETIN | Antimicrobial resistance is a major health problem that is complicated by social, cultural and economic factors that lead to the misuse, overuse and abuse of life-saving antimicrobial medicines. To help address this challenge, the International Network for Antimicrobial Resistance Social Science (INAMRSS) has been created. The network is an open consortium of social science researchers focused on addressing the global challenge of antimicrobial resistance. Antimicrobial resistance is only surmountable through efforts that consider social, political and economic factors. The network intends to champion social science as part of a broadly defined One Health perspective to inform global initiatives. INAMRSS is a member of the Global AMR R&D Hub stakeholder group. Article co-authored by Kevin Outterson, Executive Director of CARB-X.