CLINICAL INFECTIOUS DISEASES / OXFORD ACADEMIC | This article examines the WHO Leveraging Vaccines to Reduce Antibiotic Use and Prevent AMR Framework. Written by Johan Vekemans and distinguished colleagues, the article concludes that successful health interventions depend on public confidence. Advocacy and targeted communication is needed to raise awareness about the benefits of vaccines. Policy makers, influencers as well as the scientific and medical community have a major role to play in raising awareness about the importance of protecting people against infections and curbing the threat that AMR poses to individuals, societies and global health.