Padmini Srikantiah, Antimicrobial Resistance Strategy Lead at the Bill & Melinda Gates Foundation, examined the economic and societal benefits of vaccines in preventing antibiotic-resistant infections and disease and the lessons learned from the COVID-19 pandemic to accelerate the delivery of life-saving vaccines to the world. The presentation was made at Decennial Day, April 12, 2021. The Decennial Conference reviews the advances of the previous decade and the opportunities and trends for the fields of healthcare epidemiology, infectious diseases, and infection prevention and control for the future. Co-hosted by the Society for Health care Epidemiology of America (SHEA) and the Centers for Disease Control and Prevention (CDC), the Decennial Program focused on global solutions for preventing healthcare-associated infections and addressing emerging pathogens and antibiotic resistance in healthcare.