Boston University Professor Kevin Outterson examines the economic barriers to AMR innovation and potential solutions to create a sustainable environment for antibacterial innovation to address the rise of resistance. The presentation was made at Decennial Day, April 12, 2021. Held once every ten years, the Decennial Conference reviews the advances of the previous decade and the opportunities and trends for the fields of healthcare epidemiology, infectious diseases, and infection prevention and control for the future. Co-hosted by the Society for Health care Epidemiology of America (SHEA) and the Centers for Disease Control and Prevention (CDC), the 2021 Decennial Program focused on global solutions for preventing healthcare-associated infections and addressing emerging pathogens and antibiotic resistance in healthcare.