ISDA GLOBAL HEALTH | To date, there are limited data on superinfections associated with the novel coronavirus SAR-CoV-2. A handful of published reports, however, largely from China, suggest that bacterial and fungal superinfections may occur in a significant percentage of patients with severe COVID-19, and that these infections are caused at least in some hospitals by antimicrobial-resistant, nosocomial pathogens. Based on these reports, Dr. Neil J. Clancy writes in an ISDA blog there are suggestions that SARS-CoV-2 infection leads to immune system dysregulation in severe infections, which may leave patients vulnerable to bacterial or fungal proliferation, and that critically ill patients, especially those in intensive care units or receiving mechanical ventilation, are at markedly increased risk for bacterial and fungal infections, independent of COVID-19.