THE LANCET | The COVID-19 pandemic is a wake-up call that global collaboration is the most effective way to tackle global health threats. In 2020 and beyond, we cannot afford to ignore antimicrobial resistance (AMR). A coordinated One Health response is needed, with action from multisectoral and cross-sectoral stakeholders in human and veterinary medicine, agriculture, finance, environment, industry, and consumers, to address what is as much an environmental issue as an economic one. Through leadership and accountability, national governments can be greater than the sum of their parts.