Beginning on 1 December 2025 at 10:00 ET, applicants can submit an Expression of Interest for the two funding themes. Applicants who have not yet applied will be first asked to register in the CARB-X Portal. To register and to submit an Expression of Interest, click on the button below.
Target Product Profiles and minimal entry criteria for each theme can be found here. Below are EOI templates for both funding themes.
2025 EOI template for therapeutics for infections caused by Gram-negative pathogens
2025 EOI template for diagnostics for typhoid fever for low-resource settings
We highly encourage you to read our Frequently Asked Questions.
Public webinars will be held on 4 December and 5 December to discuss the scope of the funding round and application process, as well as share tips for submitting a good Expression of Interest. Webinar attendees will also have the opportunity to ask the CARB-X team questions.
Thursday, 4 December at 19:00 ET
Register here: bit.ly/4nwr4ES
Friday, 5 December at 09:00 ET
Register here: bit.ly/4ofT6We
Expressions of Interest (EOI) for both themes may be submitted from 1 December 2025 at 10:00 ET to 12 December 2025 at 23:59 ET.
In the EOI, you will be asked to answer a series of questions about your proposed project and will be given the opportunity to share pertinent, non-confidential details, in free text. Your application will be judged on the merits of its scientific content; describe your science with as much data as possible. Please do provide sufficient data to allow a knowledgeable scientist to get a reasonable sense of the therapeutic/preventative/diagnostic. Do not provide other manuscripts, references, citations or similar. Note that the form can only accept text; you may not enter tables or graphics. Do not include foundational information regarding the significance of antibiotic resistance; this is not necessary, as the reviewers understand this.