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SUMMARY:Live Webinar: GARDP/REVIVE – Manipulating the host response to treat infections
DESCRIPTION:Immune modulation and host directed therapies as an adjunctive approach to treating infections (R.E.W. (Bob) Hancock):  \n\nHost defence peptides (HDP; often termed antimicrobial peptides) stimulate protective immunity while suppressing potentially harmful inflammation. Both of these activities can assist in anti-infective therapy.\nHDPs work as immune modulators in animal models against ESKAPE pathogen\, MDR TB\, fungal\, malaria and viral infections\, as well as sterile inflammation. They are likely to be employed in adjunctive therapy in combination with antibiotics.\nHDPs often have additional value-added activities including action against bacterial biofilms in animal models. This allows them to be utilized to address situations where antibiotics commonly fail.\nAlternative host-directed therapies can be defined for recalcitrant infections using stem cell mutagenesis and systems biology approaches.\n\nRegulation and reprogramming of the innate immune system as alternative to antibiotics (Henk P. Haagsman):  \n\nHost defence peptides (HDP) are immunomodulatory antimicrobials. – Cathelicidin-derived peptides may serve as paradigms to develop anti-inflammatory anti-infectives.\nCathelicidin-derived peptides may be used prophylactically as immunomodulators and adjuvants in veterinary medicine.\nHost-directed therapy may include innate immune training by epigenetic reprogramming. The presentations will be followed by a Q&A session.\n\nSpeakers: R.E.W. (Bob) Hancock\, University of British Columbia (Canada); Henk P. Haagsman\, Utrecht University (Netherlands) \nModerator: Neeloffer Mookherjee\, Departments of Internal Medicine and Immunology\, University of Manitoba (Canada) \nClick here to learn more and register.
URL:https://carb-x.org/event/live-webinar-gardp-revive-manipulating-the-host-response-to-treat-infections/
LOCATION:WEBINAR\, Webinar\, Webinar\, United States
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